PRF & PRF Gel in Denver
Medically reviewed by Mary Leighton Kohlmann Smith, NP — September 2026
Simply Injectables | Denver, CO | Est. 2014
PRF and PRF Gel use your own blood to support collagen production, improve skin quality, and restore subtle volume over time.
Platelet-Rich Fibrin (PRF) is created from a small sample of your blood. Once it’s processed in a centrifuge, the solution contains platelets, fibrin, white blood cells, and growth factors that help stimulate your body’s natural healing response.
At Simply Injectables, PRF comes in two forms, and both work with your own biology instead of adding anything synthetic:
- PRF — a liquid version injected into the face, neck, hands, and scalp. It’s also what we use to support hair loss and sexual wellness.
- PRF Gel — a newer, thicker version of PRF processed to a consistency closer to filler, used to restore subtle volume in delicate areas like under the eyes.
PRF is 100% natural, derived entirely from your own blood with no synthetic additives.
PRF & PRF Gel at a Glance
Treatment type | Regenerative injectable |
Common concerns | Under-eye hollowness, skin texture, thinning hair, early volume loss, and signs of aging in the neck and hands |
Downtime | Typically 3–5 days |
Timeline | Gradual improvement over several weeks, continuing for months |
Recommended plan | 2–3 treatments spaced 4–6 weeks apart |
Approach | 100% natural, using your own biological material |
Why Patients in Denver Choose PRF & PRF Gel
A lot of patients are looking for something that works with their body instead of against it, and PRF fits that need. It uses your own biology, with no synthetic materials, and the results build gradually and naturally over time. For many people, that feels better both in how it works and how it looks.
Research into PRF is ongoing and results vary by person. If you want to learn more about the science, you can read about the natural benefits of PRF and PRF Gel here.
At Simply Injectables, the goal is always results that feel like you, just more rested, more even, or a little more refreshed.
PRF and PRF Gel
PRF and PRF Gel can be used a few different ways depending on what you’re trying to address.
PRF, the liquid form, is injected into the under-eye area, cheeks, neck, hands, and scalp to support tissue health and skin quality from within. It’s also the form we use to support sexual wellness for women, and you can read more about that on our PRF for Sexual Enhancement page.
PRF Gel is a newer version processed into a thicker consistency. It’s used in areas where a small amount of volume makes a real difference, especially under the eyes. Because it comes from your own blood, it works well in delicate areas where the skin is thin and traditional filler can feel too heavy.
The gel looks and feels more like a filler, but it’s still 100% natural. PRF and PRF Gel can also be combined with dermal filler for an enhanced result.
PRF Compared to Other Options
| Feature | PRF / PRF Gel | PRP | Dermal Fillers |
| Source | Your own blood | Your own blood | Synthetic (hyaluronic acid) |
| Growth factor release | Gradual (fibrin matrix) | Faster release | Not applicable |
| Focus | Skin quality, hair, and subtle volume | Skin quality | Immediate volume |
| Natural | 100% natural | Natural | Synthetic |
| Timeline | Builds over time | Builds over time | Immediate change |
What PRF Can Help With
Skin Quality and Collagen Support
Collagen naturally declines over time, and that’s when changes in texture, elasticity, and brightness start to show. PRF supports the skin by delivering growth factors that signal your body to rebuild and repair, which over time can lead to smoother texture and more even tone.
Under-Eye Hollowness
The under-eye area is often one of the first places people notice changes. PRF Gel is used here to add a small amount of volume while also supporting the skin itself, with the goal of a softer, more rested appearance.
Hair and Scalp Health
PRF can also be used on the scalp to support thinning hair and overall scalp health, using the same growth factors that help rebuild skin quality elsewhere on the face and body.
Neck and Hand Rejuvenation
PRF and PRF Gel can also be injected into the neck and hands to support skin quality and tissue health in areas that show early signs of aging.
Sexual Wellness
PRF is also used to support sexual wellness for women. Visit our PRF for Sexual Enhancement page to learn more about that treatment specifically.
Am I a Good Candidate for PRF?
PRF may be a good fit for people who:
- want a natural approach to skin and hair rejuvenation
- are comfortable with gradual improvement over time
- are noticing early signs of volume loss, thinning hair, or skin changes
- want to address under-eye concerns without traditional filler
- are interested in PRF for sexual wellness, neck, or hand rejuvenation
It’s not appropriate for everyone. If you smoke, you may see less benefit from PRF, since smoking affects circulation and your body’s ability to heal and produce collagen. Certain medical conditions may also affect whether PRF is right for you, and we’ll review all of this during your consultation.
Who Performs PRF Treatments at Simply Injectables?
All treatments at Simply Injectables are performed by licensed medical professionals with specialized training in injectables and facial anatomy.
The practice has been established since 2014 and is led by experienced providers who focus specifically on aesthetic and regenerative treatments.
How PRF Fits Into a Treatment Plan
PRF can be done on its own or as part of a broader plan depending on your goals.
Some patients also include:
- Botox for expression lines
- Dermal fillers for added structure or volume
- PRF for Sexual Enhancement
You can review a full list of our services and pricing here.
Getting Ready and Aftercare
A few small steps can help your results. If possible, avoid antihistamines for 24 hours before your appointment and for three days after, since they can affect how your body responds to treatment. Eating foods rich in vitamin C in the days around your appointment also supports collagen production, so it’s worth adding a little extra to your plate.
Frequently Asked Questions About PRF Facial Treatment in Denver
Most people start with a series of 2–3 treatments spaced 4–6 weeks apart, followed by maintenance once or twice a year.
Appointments usually take about 60–90 minutes.
Some changes may be noticeable within a few weeks, with continued improvement over a few months.
There is some mild discomfort during the blood draw and injections. Numbing cream is used to help with comfort.
PRF is processed differently than PRP, which allows it to retain additional components, including a fibrin matrix, and release growth factors over a longer period of time. PRF Gel is the newest version, which creates a thicker, more filler-like consistency from the blood.
Mild redness, swelling, or bruising is common for a few days.
Yes, PRF can be combined with dermal filler for enhanced results, depending on your goals and treatment plan.
At Simply Injectables, we primarily use PRF and PRF Gel in the under-eye area and cheeks, but it can also be used in the neck, hands, and scalp.
Yes. PRF is often used on the scalp to support hair thickness and scalp health, in addition to its use in the face, neck, and hands.
Yes. Smoking can reduce how well PRF works because it affects circulation and your body’s ability to heal and produce collagen.
If possible, avoid antihistamines for 24 hours before and three days after your appointment. Eating foods rich in vitamin C around your treatment date can also support collagen production.
What to Expect at Simply Injectables
The process starts with a consultation where your provider evaluates your skin and talks through your goals.
From there, a plan is created based on your timeline and what feels realistic for you.
Treatments are performed with a focus on balance, comfort, and natural-looking results.
Book Your PRF Consultation in Denver
If you’re considering PRF, the next step is a consultation to see if it fits your goals.
You can book your consultation for PRF in Denver online here.
Important Information
Simply Injectables is located in Denver, Colorado. PRF and PRF Gel treatments are performed by licensed medical professionals. Individual results vary. This content is for informational purposes only and does not replace medical advice.