Medically reviewed by Mary Leighton Kohlmann Smith, NP — July 2026
Simply Injectables | Denver, CO | Est. 2014
Radiesse is an FDA-approved injectable made of calcium hydroxylapatite (CaHA), a mineral compound your body already produces naturally in bones and teeth. In its standard form, Radiesse is used to add structural volume to areas like the cheeks and jawline. When it’s diluted with saline, it becomes a different kind of treatment altogether, one focused on skin quality rather than volume.
This diluted approach, known as hyperdilute Radiesse, spreads more evenly through the skin’s surface layers and works as a biostimulator, meaning it encourages your body to build its own collagen rather than adding bulk. At Simply Injectables, hyperdilute Radiesse is most often used on the neck, hands, and décolletage, areas that show early signs of aging through texture and laxity rather than volume loss.
Hyperdilute Radiesse is commonly used to address:
Rather than filling a specific line or fold, hyperdilute Radiesse works across a broader area to improve the skin’s overall thickness, elasticity, and firmness.
Before treatment: Your provider will assess your skin quality and goals to determine the right dilution and treatment plan for your specific concerns.
During treatment: The diluted Radiesse solution is injected in a series of small deposits across the treatment area, allowing it to spread evenly through the skin’s surface layers.
After treatment: Mild swelling or bruising is possible but typically resolves within a few days. There’s no significant downtime, and most patients return to their normal activities right away.
Results build gradually as your body responds to the collagen-stimulating effect, with continued improvement over several months following treatment.
Standard Radiesse is used at full concentration to restore structural volume in areas like the cheeks or jawline, similar to how Voluma is used for cheek volume. Hyperdilute Radiesse takes that same CaHA microsphere technology and dilutes it with saline, which changes how it behaves once injected.
Instead of sitting in one place to create volume, the diluted solution spreads through the superficial layers of the skin and stimulates collagen and elastin production across the treated area. The result is improved skin quality and tightness rather than added structure, which is why it’s the preferred approach for areas like the neck and hands where volume isn’t the primary concern.
If you’re curious whether hyperdilute Radiesse is the right fit for your skin, book a consultation or call 303-888-0103 to get started.
Important Information
Radiesse is an FDA-approved injectable treatment performed by licensed medical professionals. The hyperdilute technique described on this page is an off-label use for skin quality and tightening. Individual results vary. This content is for informational purposes only and does not replace medical advice.
